Peer-Reviewed Articles Authored or Co-authored by Members of the Centre
Preparation and structure of a new coagulation factor XI catalytic domain for drug discovery.
Jiang, L.-G., Yuan, C., Chen, H.-W., Wang, Y., Zhao, B.-Y., Zhang, X., and Huang, M.-D. (2011) in press.

DNA methylation profiles of protease nexin 1 (SERPINE2) gene in human cell lines.
Gao, S., and Andreasen, P.A. (2011) Chinese J. Cancer Res., in press.

MMP9 is protective against lethal inflammatory mass lesions in the mouse colon.
Hald, A., Rønø, B., Melander, M.C., Ding, M., Holck, S., Lund, L.R. (2011) Dis. Model Mech. 4, 212-27.

Expression of C4.4A, a structural uPAR homolog, reflects squamous epithelial differentiation in the adult mouse and during embryogenesis
Kriegbaum, M.C., Jacobsen, B., Hald, A., and Ploug M. (2011) J. Histochem. Cytochem. (2011) 59, 188–201.

Structural basis for recognition of urokinase-type plasminogen activator by plasminogen activator inhibitor-1.
Lin, Z., Jiang, L., Yuan, C., Jensen, J.K., Zhang, X., Luo, Z., Furie, B.C., Furie, B., Andreasen, P.A., and Huang, M. (2011) J. Biol. Chem. 286, 7027-7032.

Expression, purification and characterization of recombinant jerdonitin, a P-II class snake venom metalloproteinase comprising metalloproteinase and disintegrin domains. Zhu, L.L., Yuan, C., Chen, Z., Wang, W.Y., and Huang, M.D. (2010) Toxicon 55, 375-380.

Crystal structure of a triacylglycerol lipase from Penicillium expansum at 1.3 Å determined by sulfur SAD.
Bian, C., Yuan, C., Chen, L., Meehan, E.J., Jiang, L., Huang, Z., Lin, L., and Huang, M. (2010) Proteins 78, 1601-1605.

Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: Structure of a complex between the C2 domain and an inhibitor of membrane binding.
Liu, Z., Lin L., Yuan, C., Nicolaes, G.A., Chen, L., Meehan, E.J., Furie, B., Furie, B., and Huang, M. (2010) J. Biol. Chem. 285, 8824-8829.

Serum-stable 2'-fluoro-pyrimidine-modified RNA aptamers binding to urokinase-type plasminogen activator and blocking the association to its receptor.
Dupont, D.M., Madsen, J.B., Hartmann, R.K., Tavitian, B., Ducongé, F., Kjems, J., and Andreasen, P.A. (2010) RNA 16, 2360-2369.

Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation.
Connolly, B.M., Choi, E.Y., Gårdsvoll, H., Bey, A.L., Currie, B.M., Chavakis, T., Liu, S., Molinolo, A., Ploug, M., Leppla, S.H., and Bugge, T.H. (2010) Blood, 116, 593-1603.

Pentalysine b-carbonylphthalocyanine Zinc: An effective tumor-targeting photosensitizer for photodynamic therapy.
Chen, Z., Zhou, S., Chen, J., Deng, Y., Luo, Z., Chen, H., Hamblin, M.R., and Huang, M. (2010) ChemMedChem 5, 890-899.

Purification and characterization of recombinant full-length and protease domain of murine MMP-9 expressed in Drosophila S2 cells.
Rasch, M. G., Lund, I. K., Illemann, M., Høyer-Hansen, G., Gårdsvoll, H. (2010) Protein Expr. Purif. 72, 87-94.

RNA aptamers as conformational probes and regulatory agents for plasminogen activator inhibitor-1.
Madsen, J.B., Dupont, D.M., Andersen, T.B., Nielsen, A.F., Sang, L., Brix, D.M., Jensen, J.K., Broos, T., Hendrickx, M., Christensen, A., Kjems, J., Andreasen, P.A. (2010) Biochemistry 49, 4103-4115.

Epigenetic alterations of the SERPINE1 gene in oral squamous cell carcinomas and normal oral mucosa.
Gao, S., Nielsen, B.S., Krogdahl, A., Sørensen, J.A., Tagesen, J., Dabelsteen, S., Dabelsteen, E., and Andreasen.   P.A. (2010) Genes Chromosomes Cancer 49, 526-538.

Structure-based engineering of species selectivity in the uPA•uPAR interaction. Implication for preclinical cancer therapy
Lin, L., Gårdsvall, H., Huai, Q., Huang, M. And Ploug, M. (2010) J Biol Chem. 285, 10982-10992.

MT1-MMP and type II collagen specify skeletal stem cells and their bone and cartilage progeny.
Szabova, L., Yamada, S.S., Wimer, H., Chrysovergis, K., Ingvarsen, S., Behrendt, N., Engelholm, L.H. and Holmbeck, K. (2009) J. Bone Miner. Res. 24, 1905-1916.

The collagen receptor uPARAP/Endo180.
Engelholm, L.H., Ingvarsen, S., Jürgensen, H.J., Hillig, T., Madsen, D.H., Nielsen B.S., and Behrendt, N. (2009) Front. Biosci. 14, 2103-2114.

Challenges for drug discovery - A case study of urokinase receptor inhibition.
Chen, Z., Lin, L., Huai, Q., and Huang, M. (2009) Comb. Chem. High Throughput Screening 12, 961–967.

Crystal Structures of urokinase-type plasminogen activator in complex with 4-(aminomethyl) benzoic acid and 4-(aminomethyl-phenyl)-methanol.
Jiang, L.G., Zhao, G.X., Bian, C.B., Yuan, C., Huang, Z.X., and Huang, M.D. (2009) Chin. J. Struct. Chem. 28, 253-259.

Nonproteolytic induction of catalytic activity into the single-chain form of urokinase-type plasminogen activator by dipeptides.
Bøtkjaer, K.A., Byszuk, A.A., Andersen, L.M., Christensen, A., Andreasen, P.A., and Blouse, G.E. (2009) Biochemistry 48, 9606-9617.

The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice
Gao, S., Dagnaes-Hansen, F., Nielsen, E.J.B., Wengel, J., Besenbacher, F., Howard, K.A., and Kjems, J. (2009) Mol. Ther. 17, 1225-1233.

Comparative analysis of metastasis variants derived from human prostate carcinoma cells: roles in intravasation of VEGF-mediated angiogenesis and uPA-mediated invasion
Conn, E.M., Bøtkjaer, K.A., Kupriyanova, T.A., Andreasen, P.A., Deryugina, E.I., and Quigley, J.P. (2009) Am. J. Pathol. 175, 1638-52.